Product Description
Nutralighting Anemarrhena Extract (Zhi Mu Extract)- a botanical ingredient for joint and metabolic health, centered on standardized timosaponin and mangiferin.
Product Description
Anemarrhena Extract ( Zhi Mu Extract) is a concentrated powdered extract of characteristic active components refined from specific plant materials, with timosaponin as the main active component. It meets the quality standard of 10%-98% timosaponin AIII, and has multiple applications in joint health, inflammation management, and blood sugar health. It is widely used in dietary supplements, functional foods, and personal care products. Zhi Mu Extract selects the authentic Zhi Mu rhizome from Hebei, prepared using water-ethanol extraction and membrane separation processes, meeting content standards for timosaponin and mangiferin, making it a high-quality raw material for joint and metabolic health products.
Zhi Mu is a classic Chinese medicine used to clear heat and reduce fire. Weichang in Hebei is a genuine production area. In traditional applications, Zhi Mu Extract is used for heat clearing and metabolic health and is a common raw material in related Chinese medicine preparations.
Why Choose Nutralighting
Flexible Specification Customization: Supports customization of extraction ratio, standardization level, and packaging specifications on demand.
Stable Supply and Compliance: Complete COA/MSDS, supports customization and regulatory consultation.
Basic Information
| Project | Content |
| Extract Name | Anemarrhena Extract |
| Botanical name | Anemarrhena asphodeloides Bge. |
| Part used | Rhizome |
| Common English Name | Zhi Mu Extract |
| Extraction solvent | Water / Ethanol (customizable) |
| Main Components | Anemarrhena Saponins (Timosaponin) |
| Main Specifications | Anemarrhena Saponin AIII 10%-98% |
| Standardized options | 5% / 10% Timosaponins; 5% / 10% Flavonoids; or unstandardized as per buyer requirement |
| Particle size | 80-100 mesh (standard) |
| Target Market | China, Japan |
| Core Application Areas |
|
Standard Specifications (COA)
The following specifications are general reference values; please refer to the COA report of each batch for specifics.
| Testing Items | Standard |
| Anemarrhena Saponin (Timosaponin) | Anemarrhena Saponin AIII 10%-98% |
| Loss on Drying | ≤5.0% |
| Total Ash | ≤6.0% |
| Lead (Pb) | ≤1.0 mg/kg |
| Arsenic (As) | ≤2.0 mg/kg |
| Cadmium (Cd) | ≤0.5 mg/kg |
| Mercury (Hg) | ≤0.1 mg/kg |
| Pesticide Residues (Organochlorine/Organophosphorus) | Complies with USP <561> |
| Aflatoxin B1 | ≤5.0 μg/kg |
| Total Aflatoxins | ≤10.0 μg/kg |
| Total Microbial Count (TAMC) | ≤1×10⁴ CFU/g |
| Yeasts and Molds (TYMC) | ≤1×10² CFU/g |
| Escherichia coli | Not detected (1g) |
| Salmonella | Not detected (1g) |
Introduction to Plant Material
The raw material of Anemarrhena Extract product is the dried rhizome of Anemarrhena asphodeloides Bunge, a plant of the Liliaceae family. It is mainly produced in Hebei, Liaoning, Inner Mongolia, Shanxi, and other regions. Anemarrhena is an important herb in Traditional Chinese Medicine for clearing heat and purging fire. It is recorded in Volume I of the 2020 edition of the Chinese Pharmacopoeia.
Core Benefits
Anemarrhena asphodeloides extract has a traditional basis for applications in joint health and inflammation management. Its core active components, timosaponin and mangiferin, have shown certain anti-inflammatory and antioxidant activities in in vitro studies. Some research suggests that these components may be involved in regulating glucose metabolism (such as affecting α-glucosidase-related pathways). Relevant conclusions are mainly based on in vitro and animal experiments. Specific effects need to be comprehensively evaluated in combination with product form and usage dosage, and claims in end products should comply with the regulations of the sales territory.
Regulatory and Regional Access Status
The following information is organized based on publicly available regulatory data. Actual market access should be based on the latest regulations of the target country.
| Region/Country | Regulatory Status | Key Notes |
| European Union (EFSA) | Traditional herbal medicine / Food supplements | EU Directive 2004/24/EC regulates traditional herbal medicines; extracts used as ingredients in food supplements must comply with EU Novel Food Regulation (EU) 2015/2283 requirements (some traditional herbs benefit from a simplified procedure). |
| China (NHC/NMPA) | Health food ingredients / New resource foods | Based on the 2020 edition of the Chinese Pharmacopoeia and standards such as GB 16740; some varieties are included in the health food ingredient catalog or can be used in ordinary food catalogs, and the latest regulatory status of each variety must be verified specifically. |
| Japan (MHLW) | Food additives / Health food ingredients | Extracts are used as food additives or ingredients in health foods; some varieties need to be declared under the functional food labeling system. |
Application Directions and Recommended Dosage
| Application Direction | Recommended Addition Amount | Applicable Dosage Form | Remarks |
| Oral solid drinks / instant powder | According to specifications | Stick, bag, can packaging | Can be blended with other functional ingredients, recommended to control dosage using standardized extracts |
| Compressed candy / capsules | According to specifications | Tablets, hard capsules | Each capsule recommended to contain 250~500 mg of extract, 2~3 times daily |
| Oral liquid / functional beverages | According to specifications | Glass bottles, PET bottles | It is recommended to disperse in warm water before adding to the system, paying attention to pH stability |
| Personal care skincare products | 0.1~2.0%(w/w) | Lotion, serum, mask | Solubility and stability need to be evaluated according to the formulation system |
Recommended Daily Dosage Reference
The following dosage benchmarks are explicitly defined for the finished extract powder obtained by water extraction/ethanol extraction from the dried rhizome of Anemarrhena asphodeloides, not for the dosage of dried Anemarrhena asphodeloides decoction pieces:
- For daily health care internal administration, the recommended dosage is 1.5-3 grams per day, taken with warm water in two divided doses after meals to reduce gastrointestinal irritation.
- For medicinal conditioning, it should be used under the guidance of a traditional Chinese medicine practitioner, with a maximum dosage not exceeding 6 grams per day and a consecutive administration period not exceeding 2 weeks.
- For high-purity total saponin extracts (with saponin content > 30%), the dosage shall be further halved in accordance with the product labeling, and the dosage of ordinary extracts shall not be directly applied as a reference.
Other Notes
- Contraindications: Individuals with spleen and stomach deficiency with cold symptoms and aversion to cold; those with chronic loose stools; those with an unresolved external invasion of wind-cold; and those with kidney yang deficiency.
- Use with caution: Pregnant women, breastfeeding women, and patients with low blood pressure or chronic liver or kidney disease must consult a TCM practitioner for a differential diagnosis before use.
- Drug interactions: When used in combination with antidiabetic agents, diuretics or glucocorticoids, blood glucose, electrolyte levels and blood pressure must be monitored to avoid discomfort caused by additive effects.
- Risks of improper use: Long-term use in excessive doses may damage the yang qi of the spleen and stomach, leading to adverse reactions such as abdominal pain, diarrhoea and loss of appetite.
Appendix: References
(The following references are for technical reference; some are open access and can be accessed via PubMed/PMC or journal official websites)
[1] Lee S.H. et al., Journal of Ethnopharmacology, 2008; 118: 326-331.
[2] Yang H. et al., Journal of Ethnopharmacology, 2016; 184: 202-210.
[3] Kim H.P. et al., Life Sciences, 2005; 77: 1653-1662.
[4] Kim Hye-Min, Kang Yun-Mi, Jin Bo-Ram, et al. Anti-inflammatory Capacity of a Medicinal herb extract, Anemarrhena asphodeloides, on In vivo and In vitro models-induced atopic dermatitis. Heliyon, 2024, DOI: 10.1016/j.heliyon.2024.e37935. PMID: 39391467
[5] Liao Zhen-Dong, Sun Rou, Wang Ren-Zhong, et al. Chemical constituents from the fibrous roots of Anemarrhena asphodeloides and their in vitro cytotoxic activity. Pharmaceutical Biology, 2026, 28(4):553-560, DOI: 10.1080/10286020.2025.2529993. PMID: 40667826
[6] Yang Bing-You, Bi Xue-Yan, Liu Yan, et al. Four New Glycosides from the Rhizoma of Anemarrhena asphodeloides. Molecules, 2017, DOI: 10.3390/molecules22111995. PMID: 29165329
[7] Lee A-Y, Kim J-Y, Lee S, et al. Comparison of Various Solvent Extracts and Major Bioactive Components from Unsalt-Fried and Salt-Fried Rhizomes of Anemarrhena asphodeloides. Pharmaceuticals, 2022, 15(2):216, DOI: 10.3390/pharmaceuticals15020216. PMCID: PMC8868586
Frequently Asked Questions
Our standard Anemarrhena Extract is typically available at 5% and 10% for both timosaponins and flavonoids. Custom standardization levels are supported based on buyer specification.
Yes. Every batch is accompanied by a COA (Certificate of Analysis), heavy-metal and pesticide-residue test report, microbial analysis, and residue-solvent report in compliance with BSF requirements.
Absolutely. The standard 80-100 mesh powder is specifically optimized for direct-tableting and hard-capsule filling processes.
Our standard MOQ is 1 kg, with larger bulk quantities (25 kg drum) available for recurring orders. Please contact us for volume pricing.
Yes. Nutralighting offers OEM/ODM services including custom standardization, particle-size adjustment, and private-label packaging solutions.
Packaging & Shipping
Standard Packaging
- Standard packaging: 25 kg drum with double PE bag liner.
- Custom packaging available upon request (carton, jerry can, or IBC).
- All packaging is sealed, labelled with batch number, net weight, and storage instructions.
Shipping Terms
- Lead time: 15-25 working days after order confirmation.
- Shipping terms: FOB, CIF, CFR, or DDP (buyer's preferred port).
- Sample orders shipped via DHL / FedEx within 3-7 days.
Shelf Life & Storage
- Store in a cool, dry place away from direct sunlight and heat.
- Keep container tightly closed when not in use.
- Shelf life: 24 months from date of manufacture when stored under recommended conditions.
