A formula for weight management and gastrointestinal motility, providing standardized, traceable high-purity Synephrine Bitter Orange extract raw materials – Nutralighting ensures that every batch of raw materials can withstand verification.

Product Description

Bitter Orange are the dried young fruits and unripe fruits of Citrus aurantium L., a plant of the Rutaceae family, and are essential herbs for regulating Qi in Traditional Chinese Medicine. This product centers on Synephrine as the core active ingredient, designed for formulas targeting weight management, fat metabolism, and gastrointestinal motility (Synephrine is a component of concern, and exports must comply with the regulations and content limits of the target country).

Bitter Orange Extract Synephrine is made from authentic Jiangxi sour orange raw materials, refined through low-temperature extraction and enrichment processes. It is standardized to Synephrine 6%-10% as the core active ingredient, mainly aimed at supporting weight management, fat metabolism, and gastrointestinal motility, and is widely used in dietary supplements, functional foods, and personal care products.

Bitter Orange is a classic Qi-regulating herb in Traditional Chinese Medicine, extensively used in gastrointestinal motility drugs and health supplements. Qingjiang, Jiangxi, is the authentic production area.

Why Choose Nutralighting

• Synephrine 6%-10% standardized (complemented by neoeriocitrin), Jiangxi authentic sour orange raw materials, batch-stable and traceable.
• As a trusted B2B natural-ingredient supplier, Nutralighting provides stable global supply chains, competitive factory-direct pricing, flexible custom specifications, and complete documentation including COA, MSDS.

Basic Information

Standard Specifications (COA)

The following specifications are general reference values; the specific values shall be determined by the COA report of each batch.

Introduction to Plant Raw Materials

The raw material of this product is the dried young fruit (Zhi Shi) or immature fruit (Zhi Ke) of the Rutaceae plant Citrus aurantium L. and its cultivated varieties. It is mainly produced in Jiangxi, Sichuan, Hunan, and other regions. The 2020 edition of the Chinese Pharmacopoeia Part I includes the standard for Zhi Shi. Zhi Shi is bitter, pungent, and sour in taste, warm in nature, enters the spleen and stomach meridians, and has the effects of breaking Qi, reducing food accumulation, resolving phlegm, and dispersing abdominal distension.

Core Effects

Zhi Shi/Zhi Ke (Citrus aurantium) is used in traditional Chinese medicine to regulate Qi, reduce food accumulation, resolve phlegm, and disperse abdominal distension. Modern research primarily focuses on gastrointestinal motility and weight management. Its core active ingredients include synephrine (standardized to 6%-10%) and neohesperidin (3%-8%). In vitro and some clinical studies show that the related components may help promote gastrointestinal peristalsis, increase resting metabolic rate, and demonstrate certain angiotensin-converting enzyme (ACE) inhibitory activity. Since synephrine is a component of concern, the specific effects and safety need to be comprehensively evaluated in combination with the dosage form, dosage, and applicable regulations.

Regulatory and Regional Access Status

Since synephrine is a regulated or restricted ingredient in some countries/regions, please confirm the regulations and content limits of the target country before purchasing or formulating. The following information is compiled based on publicly available regulatory data. Actual market access should be subject to the latest regulations of the target country.

Application Directions and Recommended Dosage

Recommended Daily Dosage Reference

The dosage of Trifoliate Orange extract must be strictly controlled according to its active ingredient content; it must not be taken in high doses over a prolonged period without medical supervision.

• Converted to raw herbal equivalent: the daily dose for adults is 3-10 grams of raw Trifoliate Orange; in severe cases, a dose of up to 15 grams may be taken for a short period following a doctor’s assessment.
• Based on standard commercial specifications (6% synephrine): daily synephrine intake should be limited to 20-30 milligrams, with no single dose exceeding 15 milligrams.
• For high-purity synephrine formulations (10% or 30%), the dosage must be halved or reduced further; it is strictly prohibited to convert dosages based on the proportions of the raw herbal material.

Other Precautions

• Absolute contraindications: Not to be used by pregnant women, as the extract stimulates the uterus, significantly increasing the risk of miscarriage and premature birth.
• High-risk groups: Not to be used by patients with hypertension, arrhythmia, glaucoma or benign prostatic hyperplasia, as synephrine may raise blood pressure and increase heart rate.
• Contraindications regarding drug interactions: Must not be used in conjunction with monoamine oxidase inhibitors, cardiac glycosides, ferrous sulphate preparations or calcium carbonate-based medicines, as this may lead to toxicity or render the medication ineffective.
• Warning regarding adverse reactions: Overdose may cause palpitations, dizziness, a sudden rise in blood pressure, abdominal pain and diarrhoea; if any of these symptoms occur, discontinue use immediately and seek medical attention.

Appendix: References

(The following references are for technical reference purposes; some are open access and can be accessed via PubMed/PMC or the journal’s official website.)

[1] Zhu D.Y. et al., Journal of Ethnopharmacology, 2015; 169: 371-377.

[2] Lopez V. et al., Journal of Ethnopharmacology, 2003; 86: 1-7.

[3] Blumenthal M. et al., The Complete German Commission E Monographs, 1998.

[4] POJSA J, ORSAK M, KNOTHEOVA Z, et al. Citrus aurantium L. Active Constituents, Biological Effects and Extraction Methods. An Updated Review[J]. Molecules, 2021, 26(11): 3223.

[5] LIU Y, JIANG Y, BAI X, et al. Prokinetic effects of Citrus reticulata and Citrus aurantium extract with/without Bupleurum chinense using multistress-induced delayed gastric emptying models[J]. Journal of Ethnopharmacology, 2023, 316: Article 116727.

[7] ABDELSALAM R M, EL-SAYED Y M, AHMED H H, et al. Citrus reticulata peel extract mitigates oxidative stress and liver injury induced by abamectin in rats[J]. Environmental Science and Pollution Research, 2022, 29(42): 63307-63319.