We supply standardized and traceable high-purity Coptis chinensis extract raw material. Its core active marker is berberine. It is suitable for formulas for glucose and lipid metabolism, gut health and heat-clearing use. Every batch of our material can pass strict tests.

Product Description

Our Coptis extract powder goes through strict quality control in the whole production process. Each batch is tested separately for heavy metals, pesticide residues, microbes and aflatoxins. It meets USP, EP and ISO international standards.

This concentrated powder is refined from high-quality plant raw materials, with berberine as the key marker. Its standard: berberine (HPLC) 5%-98% customizable, standard extraction ratio 5:1. Public studies show it has antibacterial, anti-inflammatory, glucose-regulating and antioxidant effects. It is widely used in dietary supplements, functional foods and personal care products for global markets.

Raw materials come from standardized planting bases in traditional producing areas. We use low-temperature drying and low-temperature dynamic extraction to keep heat-sensitive alkaloids as much as possible. Coptis is one of the oldest and best-recorded herbs in traditional Chinese medicine. It is a key raw material for gut care and metabolic health products.

Coptis chinensis Franch. is one of the most common natural sources of berberine in the world. China is its major producing area. Coptis from Shizhu, Chongqing has stable berberine content of 7.0%-8.5%, higher than the minimum 5.5% required by Chinese Pharmacopoeia. There is a saying in the industry: “The best Coptis comes from Shizhu”. This herb has been used in traditional Chinese medicine for more than 2,000 years. Its safety and use are recognized by Chinese Pharmacopoeia and WHO monographs.

Why Choose Nutralighting

We adopt low-temperature dynamic extraction, vacuum concentration and spray drying (or freeze drying). This keeps berberine content stable and maintains good bioactivity. We offer full customization: different extraction ratios (5:1-20:1) and berberine grades (5%,10%,20%, berberine HCl 97%/98%) to match your product needs.

Our products follow USP, EP and Chinese Pharmacopoeia (ChP). Each batch comes with complete COA, including berberine and other alkaloid profiles, loss on drying, total ash, heavy metals (Pb, As, Cd, Hg), pesticide residues, aflatoxins and full microbial tests.

Basic Information

Standard Specifications (COA)

The following specifications are general reference values; the specific values are subject to each batch COA report.

Introduction to Plant Raw Materials

The raw material is dried rhizome of Coptis chinensis Franch. (Ranunculaceae). Coptis deltoidea C. Y. Cheng et Hsiao and Coptis teeta Wall. are also accepted by pharmacopoeia, named Weilian, Yalian and Yunlian. Coptis mainly grows in Sichuan, Chongqing, Hubei and Shaanxi. Shizhu, Chongqing is a geographical indication area with mature planting and primary processing standards.

Coptis has been used in traditional Chinese medicine for clearing heat, drying dampness and removing toxin for over 2,000 years and is listed in Chinese Pharmacopoeia. Its main active ingredients are isoquinoline alkaloids. Berberine has the highest content and the most research support as the marker compound.

Core Efficacy

Many public studies support its antibacterial, anti-inflammatory, glucose-lipid regulating and gut-protective effects. Berberine acts on many inflammatory and metabolic signal pathways.

• Antibacterial & anti-inflammatory: Berberine stops bacterial DNA and protein synthesis. It shows clear in vitro inhibition against H. pylori, Staphylococcus aureus and Shigella dysenteriae. It reduces NF-κB activation and the release of inflammatory factors such as TNF-α, IL-6, IL-1β.
• Glucose metabolism: Berberine activates the AMPK pathway to improve insulin sensitivity and insulin resistance. Public clinical studies show it helps lower fasting blood glucose and HbA1c. It is a popular natural ingredient for metabolic health formulas.
• Gut health: Research shows berberine balances gut microbiota, protects intestinal barrier and eases colon inflammation. It may shorten the course of infectious diarrhea. A randomized controlled study published in Lancet Gastroenterology & Hepatology (2020) found that berberine (0.3 g twice daily) reduced the recurrence risk of colorectal adenoma by about 23% (RR 0.77). Mild constipation was the main side effect.
• Lipid & antioxidant: Berberine helps adjust blood lipid levels, lowering total cholesterol, triglycerides and LDL-C. The extract also has antioxidant effects, suitable for soothing and anti-irritant formulas.

Note: The above mechanism content is for research and reference only. It does not make treatment claims for finished products.

Regulatory and Regional Access Status

Notice: Rules may change. Confirm the latest compliance with local regulators or professional consultants before export.

Application Directions and Recommended Dosage

Recommended Daily Dosage Reference

• Raw Coptis powder: 0.3-0.6 g/day; decoction: 1.5-3 g/day, compatible with other herbs.
• Standardized Coptis extract (5:1-10:1): 100-300 mg/day, the common safe range for daily health support.
• High-purity berberine (≥97%): 300-900 mg/day, taken with meals in divided doses. Do not exceed 900 mg per day. Not for pregnant women.

Other Precautions

Most adults tolerate proper berberine and Coptis extract well. Overdose may cause mild stomach discomfort such as constipation or abdominal pain. Sensitive people may get skin reactions.

Coptis P.E. product cannot replace prescription medicine for infectious diarrhea, diabetes or hyperlipidemia.

Pregnant women must not use products containing this extract. Lactating women, users of hypoglycemic drugs or anticoagulants, people with G6PD deficiency, hemolytic anemia, cold-spleen syndrome (long-term loose stool, cold intolerance) or allergy history should consult a doctor before using related products.

There is not enough safety data for infants and people with poor liver or kidney function. Long-term or high-dose use is not recommended to avoid organ burden.

Appendix: References

(The following references are for technical reference; some are open access and can be consulted via PubMed/PMC or journal websites)

[1] Pharmacopoeia of China, 2020 Edition, Part I (Coptis standard)

[2] Yan J. et al., Scientific Reports, 2015: Multicenter randomized controlled trial of berberine in type 2 diabetes

[3] Zhong S. et al., Journal of Ethnopharmacology, 2017: Review of the pharmacological effects of berberine

[4] European Medicines Agency (EMA), Coptidis Rhizoma, 2018

[5] Xiao, C. M., Zhang, K. Q., Lei, Y., Dai, H. P., Xie, M. Z., & Wang, H. Z. (2026). Integrated bioinformatics and molecular docking analysis reveals potential mechanisms of Coptidis Rhizoma in intervertebral disc degeneration. OMICS: A Journal of Integrative Biology, 30(9), 505–514.

[6] Chen, L., Yuan, S., Wang, R., Chen, L., Zhang, B., Zhang, Z., Zhao, Y., Feng, W., Zheng, X., Li, K., & Zhou, N. (2026). Revealing the enhancing mechanism and material basis of bile-processed Coptidis Rhizoma in anti-anxiety from perspective of cross organ regulation. Journal of Ethnopharmacology, 370, Article 121969.

[7] Jiang, Y., Zhang, J., Liu, W., Qian, X., Zhuang, X., & Hu, C. (2025). Scutellariae Radix and Coptidis Rhizoma improve NAFLD via regulation of SIRT6/ACSL5 pathway and SCD1. Journal of Ethnopharmacology, 348, Article 119834.

[8] Hu, C., Cao, F., Jiang, Y., Liu, K., Li, T., Gao, Y., Li, W., & Han, W. (2024). Molecular insights into chronic atrophic gastritis treatment: Coptis chinensis Franch studied via network pharmacology, molecular dynamics simulation and experimental analysis. Computers in Biology and Medicine, 178, Article 108804.

[9] Xie, Q., Li, H., Ma, R., Ren, M., Li, Y., Li, J., Chen, H., Chen, Z., Gong, D., & Wang, J. (2022). [Study on the multi-target regulation mechanism of Coptis chinensis extract in metabolic diseases]. Phytomedicine, 97, Article 153927.