Extract from Oregon Grape (Mahonia aquifolium) root – Berberine 80-98% standardized, a natural ingredient for skin health and liver protection.

Product Description

Conduct evidence-based research and formula adaptation focusing on skin health and liver protection,

Oregon Grape Extract is refined from plant materials using a standardized process, with berberine content of 80%-98% to ensure stable berberine levels, supporting skin health, liver protection, and metabolic regulation, suitable for the development of health supplements, functional foods, and personal care products. Oregon Grape Extract is made from carefully selected authentic roots and rhizomes from the United States, prepared using ethanol extraction and standardized processing, with high berberine content, making it a high-quality raw material for skin health and metabolic regulation products.

Oregon grapes are a traditional North American herbal medicine. The Pacific Northwest of the United States and Canada are the main producing areas, and they are mainly used in the skincare and metabolic health product markets.

Basic Information

Why Choose Nutralighting

Skin evidence-based: Topical formulation studies show potential to improve mild to moderate skin discomfort (improvement in both erythema and scaling), suitable for skincare formulations.
Liver metabolism: Berberine has antibacterial and anti-inflammatory effects, regulates metabolism, and has been studied for liver protection.

Standard Specifications (COA)

The following specifications are for general reference only; the actual values shall be based on the COA report of each batch.

Introduction to Plant Materials

The raw material of this product is the dried root or rhizome of Mahonia aquifolium (Pursh) Nutt., a plant of the Berberidaceae family. It is mainly produced in the northwestern United States and British Columbia, Canada. Oregon grape is a traditional medicinal plant of Native Americans and is known as the ‘American barberry.’ Its main active ingredient is also berberine.

Core Benefits

The following summary of effects is based on published scientific research and traditional applications, and the specific effects need to be comprehensively evaluated in combination with the product form and dosage used.

In North American traditional medicine, Oregon grape is often used for skin and liver health. Research on topical preparations shows potential for improving mild to moderate skin discomfort (simultaneous improvement of erythema and scaling). Mechanism studies indicate that berberine downregulates Ki-67 and cyclin D1 expression by inhibiting the NF-κB and STAT3 pathways, reducing excessive proliferation of keratinocytes. In terms of liver protection, studies on Oregon grape extracts suggest its potential for liver protection.

Regulations and Regional Access Status

The following information is compiled based on publicly available regulatory data; for actual market access, please refer to the latest regulations of the target country.

Application Directions and Recommended Dosage

Recommended Daily Dosage Reference

• General Health Use: Use according to product specifications and the dosage recommended by the formulator
• Personal Care and Skincare: The amount added in formulations depends on the specific product, recommended 0.1~2.0%

Appendix: References

(The following references are for technical reference purposes; some are open access and can be accessed via PubMed/PMC or the journal’s official website.)

[1] Ernst E. et al., Journal of the American Academy of Dermatology, 2000; 43: 907-909.

[2] Furr H.K. et al., Journal of Ethnopharmacology, 1994; 42: 9-15.

[3] National Center for Complementary and Integrative Health, NCCIH, 2021.