Nutralighting selects high-quality whole herb Rue from the Mediterranean, standardized to lock in flavonoid components such as Rutin, providing stable and traceable plant ingredients for formulations supporting venous health, microcirculation, and antioxidants.

Product Description

Rue Extract is a concentrated powder of characteristic active ingredients refined from specific plant materials, with Rutin as the main active component. It meets the quality standard of 80%-95% Rutin, and has multiple applications including venous health, microcirculation, antioxidation, and skincare. It is widely used in health foods, functional foods, and personal care products. Rue Extract is made from selected high-quality Mediterranean whole herb Rue, prepared using ethanol extraction and spray drying processes, with stable flavonoid content, making it a high-quality ingredient for venous health, microcirculation, and skincare products.

Rue is a traditional European herb, primarily produced in Mediterranean countries, mainly used in natural products for venous health and anti-inflammatory purposes.

Why Choose Nutralighting

• Broad-Spectrum Phytochemistry: Rich in furanocoumarins (psoralen, bergapten), flavonoids (rutin, quercetin), volatile oils, and alkaloids
• Customizable Extraction: Available in ethanol, water, or supercritical CO2 extraction variants to match your formulation needs
• Standardization Options: Custom-standardized concentrations available upon request
• Sustainability: Artificial cultivation and traceable supply chain

Basic Information

Standard Specifications (COA)

The following  Rue Extract Rutin specifications are regular reference values; the actual values shall be subject to the COA report of each batch and specification.

Plant Material Introduction

The raw material is the dried whole herb of Ruta graveolens L. from the Rutaceae family. It is mainly produced in Southern Europe and the Mediterranean region. Rue has a long history in European traditional medicine. It is recorded in the European Pharmacopoeia.

Core Benefits

Extracts of Rue (Ruta graveolens extract) have traditional applications for venous health and microcirculation. Its main active component, rutin, is an effective natural antioxidant traditionally used to support capillary strength and venous health. Related applications are primarily based on traditional experience and in vitro studies. Specific effects need to be comprehensively assessed according to product form and dosage, and any claims made on final products should comply with local regulations in the sales region.

Regulatory and Regional Access Status

The following information is compiled based on publicly available regulatory data. Actual market access should follow the latest regulations of the target country.

Application Directions and Recommended Dosage

Recommended daily dosage reference

There are differences in the recommended addition amounts of rue extracts across different components and specifications:

• Rutin (80%)‌: 0.05%~0.2% in food and skincare products; the recommended maximum daily oral intake is ≤200mg.
• Rue Oil (Volatile Oil)‌: 0.0004%~0.001% for food flavoring, and ≤0.05% in skincare products.
• Whole-herb Ratio Extract (10:1)‌: ≤0.1% in common food, and 0.5%~2% in topical skincare products.
• Furanocoumarins‌: Strictly controlled at ≤0.001% in skincare products to avoid photosensitive risks caused by high concentrations.

Other Precautions

• Pregnant women, breastfeeding women and those with impaired liver or kidney function must not use this product; oral overdose may easily cause toxic reactions such as nausea and dizziness.
• As this product contains furanocoumarin, it must be kept strictly away from light after use to prevent photosensitivity reactions such as skin redness, swelling and blisters caused by exposure to sunlight.
• Do not use in conjunction with antiplatelet medication. A local skin sensitivity test must be carried out before topical application, and direct contact with mucous membranes must be avoided.
• Store in a sealed, light-protected container; prolonged exposure to light may cause the ingredients to oxidise, discolour and lose their potency.

Appendix: References

(The following references are for technical reference; some are open access and can be accessed via PubMed/PMC or journal official websites)

[1] European Pharmacopoeia 11.0, Rueherba

[2] Journal of Ethnopharmacology, 2020: Ruta graveolens pharmacological review

[3] Phytotherapy Research, 2019: Rutin and venous insufficiency

[4] EMA HMPC, Ruta graveolens whole herb monograph

[5] Pavić V, Flačer D, Jakovljević M, et al. Assessment of Total Phenolic Content, In Vitro Antioxidant and Antibacterial Activity of Ruta graveolens L. Extracts